Ana amfani da helium sosai a masana'antar soja, bincike na kimiyya, petrochemical, firiji, jiyya, semiconductor, gano bututun bututun, gwaji mai ƙarfi, masana'antar ƙarfe, ruwa mai zurfi, walƙiya mai tsayi, samar da samfuran optoelectronic, da sauransu.
(1) Ƙananan sanyi mai sanyi: Yin amfani da ƙananan tafasasshen ruwa na helium na -268.9 °C, ana iya amfani da helium na ruwa don sanyaya ƙananan zafin jiki.Fasahar sanyaya ƙananan zafin jiki mai ƙarancin zafi yana da kewayon aikace-aikace a cikin fasaha mai ƙarfi da sauran fannoni.Abubuwan haɓakawa suna buƙatar kasancewa a ƙananan zafin jiki (kimanin 100K) don nuna kaddarorin sarrafawa.A mafi yawancin lokuta, helium na ruwa ne kawai zai iya cimma irin wannan ƙananan zafin jiki cikin sauƙi..Ana amfani da fasahar haɓakawa sosai a cikin jiragen ƙasa na maglev a cikin masana'antar sufuri da kayan aikin MRI a fagen likitanci.
(2) hauhawar farashin balloon: Tunda yawan sinadarin helium ya fi na iska (yawan iskar 1.29kg/m3, adadin helium ya kai 0.1786kg/m3), kuma sinadarai ba su da aiki sosai, wato mafi aminci fiye da hydrogen (hydrogen na iya zama a cikin iska mai ƙonewa, mai yuwuwa mai fashewa), ana amfani da helium a matsayin mai cike da iskar gas a cikin jiragen ruwa ko balloon talla.
(3) Bincika da bincike: Manyan maɗaukakin maganadisu na masu nazarin tasirin maganadisu da aka saba amfani da su wajen binciken kayan aiki suna buƙatar sanyaya ta helium ruwa.A cikin bincike na chromatography gas, ana amfani da helium sau da yawa azaman iskar gas.Yin amfani da fa'ida mai kyau da rashin ƙonewa na helium, helium Hakanan ana amfani da shi wajen gano ɗigon ruwa, kamar na'urar ganowa ta helium mass spectrometer leak detectors.
(4) Garkuwa Gas: Yin amfani da kaddarorin sinadarai marasa aiki na helium, ana amfani da helium azaman garkuwar iskar gas don walda na magnesium, zirconium, aluminum, titanium da sauran karafa.
(5) Wasu al'amura: Ana iya amfani da helium azaman iskar gas mai matsewa don jigilar abubuwan motsa ruwa kamar ruwa hydrogen da oxygen ruwa akan rokoki da jiragen sama a cikin manyan na'urori masu lalata da makaman nukiliya.Ana kuma amfani da helium a matsayin wakili mai tsaftacewa ga masu sarrafa makamashin atomic, a cikin gaurayawan iskar gas don shaƙatawa a fagen raya ruwa, a matsayin iskar gas na ma'aunin zafi da sanyio, da dai sauransu.